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中国科大发现编码p53蛋白突变促进肿瘤免疫逃逸机制（图）
蛋白 肿瘤 免疫
2024/10/16
抑癌基因TP53（编码p53蛋白）通常发挥肿瘤监查的作用。TP53基因突变后转变为癌基因，是多种肿瘤发生发展的驱动因素之一。中国科学技术大学生命科学与医学部免疫调节与免疫治疗重点实验室教授魏海明课题组发现，p53可以直接调控免疫细胞的发育、分化与功能，并在肿瘤免疫微环境中发挥重要作用。p53突变导致肿瘤干细胞分泌白细胞介素34，而白细胞介素34进一步代谢重编程肿瘤相关巨噬细胞，并抑制CD8T细胞的...
2023年2月24日，中国医学科学院基础医学研究所杜文静团队在The EMBO Journal《欧洲分子生物学学会杂志》发表了“p53 protects against alcoholic fatty liver disease via ALDH2 inhibition（p53通过抑制ALDH2保护酒精性脂肪肝的发生）”文。研究报道了肿瘤抑制因子p53在抑制酒精代谢以及酒精性脂肪肝方面的重要作用。
TP53 (p53)是最重要的肿瘤抑制因子，对于维持细胞基因组完整性至关重要。为应对 DNA 损伤，p53 蛋白被激活并作为转录因子调控大量的蛋白质编码基因、微RNA（miRNA）和长非编码RNA（lncRNA）等的表达。我们前期研究发现了p53调控的LTR逆转座子衍生的lncRNA（LTR-lncRNA）促进DNA同源重组修复的新功能（EMBO Reports, 2019）。有趣的是，2022年...
中国科学院上海营养与健康研究所王莹、时玉舫研究组合作发现p53通过调控OPG影响间充质干细胞成骨分化以及肿瘤相关骨骼重塑的新机制（图）
王莹 时玉舫 p53 OPG 间充质 干细胞 成骨分化 肿瘤 骨骼重塑 新机制
2020/7/24
2020年7月22日，国际著名学术期刊Cell Death & Differentiation在线发表了中国科学院上海营养与健康研究所王莹、时玉舫课题组题为“Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoproteger...
TP53作为最著名的抑癌基因之一，其编码的p53蛋白控制着一个广泛而灵活的生物网络，并承担着基因组守护者的角色。TP53基因的缺失或突变与各种癌症的形成、发展有着至关重要的联系。正是由于p53蛋白在控制肿瘤中所具有的重要作用，不论是医药企业还是科研界都在积极地开发靶向p53生物通路的抗肿瘤候选药物。
上海交通大学医学院附属瑞金医院p53靶向药物PANDA将进入临床试验，癌症患者未来或可受益（图）
上海交通大学医学院附属瑞金医院 p53靶向药物 PANDA 临床试验 癌症患者 未来 受益
2019/9/18
2019年5月23日，上海交通大学医学院附属瑞金医院与安徽安科生物工程（集团）股份有限公司举行了PANDA项目科研转化签约仪式。标志着由瑞金医院卢敏研究员带领的“p53转化医学团队”潜心研发的抑癌蛋白p53靶向药物PANDA，将正式进入产品开发和临床试验阶段，这将是转化医学的国家战略和长三角生物医药领域产学研联动的又一硕果。瑞金医院院长瞿介明、副院长沈柏用，党委副书记俞郁萍等出席签约仪式。
Regulation of the p53 tumor suppressor gene in the mammary gland and its role in tumorigenesis
Biological sciences p53 Tumor suppressor Mammary gland Tumorigenesis
2015/1/28
Breast cancer is the most frequent tumor type among women. Heightened susceptibility of the breast to tumor development has been associated with early menarche, nulliparity, exposures to ionizing radi...
Low Levels of p53 Protein and Chromatin Silencing of p53 Target Genes Repress Apoptosis in Drosophila Endocycling Cells
apoptosis endocycling cells p53 protein
2015/1/7
Apoptotic cell death is an important response to genotoxic stress that prevents oncogenesis. It is known that tissues can differ in their apoptotic response, but molecular mechanisms are little unders...
Estrogen and progesterone regulate p53 activity in the mouse mammary epithelium through transforming growth factor beta dependent pathways
P53 protein and tumor formation mammary gland p53 fertility estrogen and progesterone p53 radiation cells DNA damage
2014/12/11
Proper regulation of the p53 protein plays a critical role in suppressing tumor formation in a variety of tissues including the mammary gland. Activity of the p53 pathway is diminished in the mammary ...
Regulation of p53 by Mdm4 and ovarian hormones in mouse mammary glands
P53 protein genome cell cycle DNA cell apoptosis cell growth breast cancer
2014/12/11
p53 protein is considered a major player in maintaining the genomic integrity. It regulates cell cycle, recognizes damaged DNA, and promotes apoptosis of cells that are defective or developmentally pr...
The role of ovarian hormones in p53-mediated resistance to mammary tumorigenesis
Pregnant breast cancer rodents estrogen and progestogen therapy breast cancer the incidence of a disease
2014/12/11
A full term pregnancy reduces breast cancer by up to 50%. In rodents, pregnancy or treatment with estrogen and progesterone to mimic pregnancy reduces mammary tumor incidence. The molecular mechanisms...
The Role Of ERα, ERβ And Phytoestrogens From Soy In P53- Mediated Response To Dna Damage In Mammary Epithelium
Biological sciences Breast cancer Estrogen receptors Mammary tumors p53 Phytoestrogens DNA damage
2014/12/11
Estrogenic compounds can stimulate proliferation of the mammary epithelium, but also potentiate the activity of the p53 tumor suppressor protein. These contradictory activities of estrogenic compounds...
Regulation of mammary stem/progenitor cells by p53 and parity
Biological sciences Progenitor cells Adult stem cells Breast neoplasms Li-fraumeni syndrome Mammary gland Notch proteins Tumor suppressor protein p53
2014/12/10
Breast cancer is the most common tumor among women with inherited mutations in the p53 gene (Li-Fraumeni syndrome). The tumors represent the basal-like subtype which has been suggested to originate fr...
P53蛋白参与灵芝酸抑制癌细胞增殖的过程
灵芝酸T P蛋白 增殖抑制 保健食品
2016/7/1
通过对灵芝三萜类物质(灵芝酸T)抑制肺癌H1299(p53-/-)细胞、肺癌95-D(p53+/+)细胞增殖实验,考察了P53蛋白对灵芝酸抑制增殖作用的影响。结果表明:通过比较IC50,表达野生型P53蛋白的95-D细胞比不表达P53蛋白的H1299细胞对灵芝酸T的敏感性高3.3倍。P53抑制剂Pifithrin-α与灵芝酸T联合处理能显著地降低灵芝酸T对95-D细胞增殖的抑制率(p0.05)。进...