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ALTERATIONS IN THE SEEKING AND SELF-ADMINISTRATION OF ETHANOL AND ANXIETY-LIKE BEHAVIOR FOLLOWING EXPOSURE TO YOHIMBINE IN RATS SELECTIVELY BRED FOR HIGH ALCOHOL INTAKE
Alcohol Anxiety Relapse Selective Breeding Stress Yohimbine
2015/1/9
Stress has been shown to contribute to alcohol drinking; however, inconsistencies in both the clinical and pre-clinical literature speak to the need for better paradigms to study this interaction. The...
通过对比多个与α2A-肾上腺素受体同属G-蛋白偶联受体的视紫红质蛋白序列,选择以相似性最大的牛视紫红质蛋白为模板,同源模建了α2A-肾上腺素受体的跨膜结构,并在结构中找到了体积为0.090 nm3,已被报导的活性残基包围的活性位点.运用分子力学与动力学方法研究了此结构突变前后与抑制剂Yohimbine的对接情况,得到了与文献报道相吻合的结果.同时对接研究结果发现,在α2A-肾上腺素受体的结合位点周...
Differential antinociceptive effects of yohimbine in the rat formalin test
Yohimbine Formalin test Antinociception Rat
2009/12/29
Although many pharmacological studies indicate that yohimbine antagonize the antinociceptive effects of α2-adrenoceptor agonists, there are evidences that yohimbine by itself produces antinociceptive ...
Mechanisms of Glybenclamide-Mediated Anti-Arrhythmia and Ischemic Conditionining in a Rat Model of Myocardial Infarction: Role of yohimbine Treatment
ATP sensitive potassium channels Hypoglycemic sulfonylurea compounds Myocardial ischemia Arrhythmia Yohimbin
2009/6/23
Glibenclamide (Glyburide), a widely used second-generation sulfonylurea hypoglycemic agent, is a known specific blocker of adenosine triphosphate (ATP) sensitive potassium (K+) channels. Although the ...
Long-lasting effects of yohimbine on the ejaculatory function in male dogs
Long-lasting effects yohimbine ejaculatory function male dogs
2009/3/3
Previous studies have demonstrated that systemic administration of a low dose of the alpha2-adrenoceptor antagonists stimulates the ejaculatory response of male dogs, when this function is analyzed us...
EFFECTS OF YOHIMBINE ON PLASMA LEVELS OF LEPTIN IN NORMAL AND STREPTOZOTOCIN INDUCED DIABETIC RATS
Diabetic rats leptin yohimbine insulin adrenoceptor streptozotocin
2010/2/4
Leptin affects paraventricular nucleus of hypothalamus and reduces appetite while activation of α2-adrenoceptors at this site has opposite action. The reducing effect of α2-adrenoceptors inhibition on...