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Solid-Phase Synthesis of N-Carboxyalkyl Unnatural Amino Acids
solid-phase synthesis amino acids combinatorial chemistry
2015/5/21
A novel route has been developed for the solid-phase synthesis of N-carboxyalkyl unnatural amino acids as potential metalloprotease inhibitors. The key step involves a nitrogen alkylation of resin-bou...
Synthesis and Calcium channel antagonist activity of Nifedipine analogues with Chloroindolyl substituent
Synthesis Calcium channel antagonist activity Nifedipine analogues Chloroindolyl substituent
2010/1/6
Various diester analogues of nifedipine in which the ortho nitrophenyl group at position 4 were replaced by 3-chloro-1H-2-indolyl substituent, were synthesized and evaluated as calcium antagonists on ...
Synthesis and smooth muscle Calcium channel antagonist effect of Alkyl, Aminoalkyl 1,4-Dihydro-2,6-Dimethyl-4-Nitroimidazole-3,5 Pyridine Dicarboxylates
Ca+² channel antagonist DHP Arylpiperazine
2009/12/29
The discovery that 1,4-dihydropyridine (DHP) class of calcium channel antagonist inhibits the Ca+² influx represented a major therapeutic advance in the treatment of cardiovascular diseases such ...
The synthesis of a panel of human monoclonal antibodies with neutralizing activities against viral infectious diseases
phage display combinatorial biology therapeutic molecule
2010/12/10
The synthesis of a panel of human monoclonal antibodies with neutralizing activities against viral infectious diseases.
Synthesis, development and preclinical comparison of two new peptide based freeze-dried kit formulation 99mTc-EDDA-Tricine-HYNIC-TOC and 99mTc-EDDA-Tricine-HYNIC-TATE for somatostatin receptor positive tumor scintigraphy
99mTc Somatostatin Tyr3-octreotide Tyr3-Octreotate HYNIC Kit formulation
2010/4/7
Somatostatin receptor (sstr) scintigraphy with [111In diethylenetriaminepentaacetic acid]-octreotide ([111In-DTPA]-OC) has became a routine diagnostic procedure in oncology. However, it suffers from s...
SYNTHESIS AND PHARMACOLOGICAL EFFECTS OF BUTADIENE AND CYCLOPENTADIENE ADDUCTS OF METHANDROSTENOLONE IN RATS
Methandrostenolone 1,3 butadiene Cyclopentadiene Diels-Alder adducts Anti-androgen
2010/2/5
In this study the reactivity of methandrostenolone or [(17b)-17-hydroxy-17-methylandrosta-1, 4-diene-3-one], as a dienophil in a Diels-Alder type cycloaddition reaction was investigated. The purpose o...
Molecular regulation of human IgE synthesis
atopy CD40 ligand IgE interleukin-4 switch recombination
2010/11/29
Human IgE synthesis is largely dependent on the production of interleukin (IL)-4 or IL-13 and the expression of CD40 ligand. Such B cell help is not only provided by CD4+ T cells, but also by CD8+ T c...