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Regional variation in macrophage antigen expression by murine epididymal basal cells and their regulation by testicular factors
Epididymis efferent duct ligation F4/80 Mac-i
2009/2/18
Factors controlling the appearance in the epididymis of basal cells and their expression of macrophage antigens were examined by ligating the efferent ducts to prevent the entry of spermatozoa in ad...
Regional variation in macrophage antigen expression by murine epididymal basal cells and their regulation by testicular factors
Epididymis efferent duct ligation F4/80 Mac-i
2009/2/18
Factors controlling the appearance in the epididymis of basal cells and their expression of macrophage antigens were examined by ligating the efferent ducts to prevent the entry of spermatozoa in ad...
Direct and indirect effects of murine interleukin-2, gamma interferon, and tumor necrosis factor on testosterone synthesis in mouse Leydig cells
murine interleukin-2 gamma interferon tumor necrosis factor testosterone synthesis
2009/2/11
It was recently observed that treatment of patients with a high dosage of human interleukin (IL-2) resulted in suppression of plasma concentrations of testosterone. A murine model was developed to a...
Regulation of caltrin mRNA expression by androgens in the murine prostate
caltrin mRNA androgens murine prostate
2008/12/26
Testicular androgens induce the proliferation and differentiation of prostatic epithelial cells by regulating the expression of androgen target genes. The use of subtractive hybridization to isolate...
Stage and region-specific localization of lipocalin-type prostaglandin D synthase in the adult murine testis and epididymis
lipocalin-type prostaglandin D synthase adult murine testis epididymis
2008/12/25
Lipocalin-type prostaglandin D synthase in semen has been associated with male fertility, although this relationship is not well defined. To gain insight into potential mechanisms, the objective of ...
Differential zinc transport into testis and brain of cadmium-sensitive and -resistant murine strains
Differential zinc testis brain cadmium-sensitive murine strains
2008/12/25
Recently, we showed that murine strain differences to the testicular toxicity of cadmium (Cd) are the result of variable transport of Cd across the blood-testis barrier. Because Cd is a nonessential...
GM1 Dynamics as a Marker for Membrane Changes Associated With the Process of Capacitation in Murine and Bovine Spermatozoa
Rafts ganglioside cholesterol cholera toxin annulus
2008/12/24
We previously showed that in live murine and bovine sperm heads, the ganglioside GM1 localizes to the sterol-rich plasma membrane overlying the acrosome (APM). Labeling GM1 using the pentameric c...
Hyalp1 in Murine Sperm Function：Evidence for Unique and Overlapping Functions With Other Reproductive Hyaluronidases
Sperm antigen, hyaluronidase activity Spam1 null sperm acrosome reaction cumulus penetration hyaluronic acid receptor
2008/12/24
While Sperm adhesion molecule 1 (SPAM1) is the highly conserved mammalian sperm hyaluronidase (hyase), multiple hyases are present in the mouse testis. In this study we show that one of the murine h...
Activation of the Nuclear Factor Kappa B Pathway Following Ischemia-Reperfusion of the Murine Testis
Testicular oxidative stress apoptosis NF-B activation
2008/12/23
Ischemia-reperfusion (IR) of the testis results in testicular oxidative stress and germ cell-specific apoptosis. Nuclear factor kappa B (NF-B) is a nuclear transcription factor involved in the control...
In Vivo Effects of Histone-Deacetylase Inhibitor Trichostatin-A on Murine Spermatogenesis
Histone mouse protamine spermatogenesis
2008/12/22
The acetylation state of core histones is controlled by two classes of enzymes, histone acetyl transferases (HATs) and histone deacetylases (HDACs). HDAC inhibitors, such as trichostatin-A (TSA), ar...
Gonadotropin-Mediated Regulation of the Murine VEGF Expression in MA-10 Leydig Cells
Testes angiogenesis ascular permeability growth factor nongenomic steroid action
2008/12/22
Presence of vascular endothelial growth factor (VEGF) is not only limited to cells directly involved in angiogenesis but has also been demonstrated in steroidogenic cells like testicular Leydig cell...
5-Aza-2'-Deoxycytidine Induces Alterations in Murine Spermatogenesis and Pregnancy Outcome
DNA methylation 5-azacytidine DNMT DNMT1 mouse fertility DNA methyltransferase
2008/12/19
Because of the ability of cytidine analogues, such as 5-aza-2'-deoxycytidine, to incorporate into DNA and lead to decreases in DNA methylation, there has recently been renewed interest in using thes...
Long-Term Culture and Transplantation of Murine Testicular Germ Cells
ROSA26 mice germ cells in vitro culture testis GCNA1 spermatozoa
2008/12/19
The objectives of this study were to develop an in vitro culture system to optimize germ cell proliferation and to measure the potential of the cultured germ cells to produce mature spermatozoa after ...