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A Mathematical Model for Interpretable Clinical Decision Support with Applications in Gynecology
Mathematical Model Interpretable Clinical Decision Support Applications Gynecology
2015/7/9
Over time, methods for the development of clinical decision support (CDS) systems have evolved from interpretable and easy-to-use scoring systems to very complex and non-interpretable mathematical mod...
Network analysis reveals distinct clinical syndromes underlying acute mountain sickness
Acute mountain sickness sleep headache visual analogue scale BioLayout Express 3D
2013/5/2
Acute mountain sickness (AMS) is a common problem among visitors at high altitude, and may progress to life-threatening pulmonary and cerebral oedema in a minority of cases. International consensus de...
Generalized Likelihood Ratio Statistics and Uncertainty Adjustments in Efficient Adaptive Design of Clinical Trials
Hoeffding’s information bound Internal pilot Kullback-Leibler information Modified Haybittle-Peto test Multiparameter exponential family Sample size re-estimation
2011/6/20
A new approach to adaptive design of clinical trials is proposed in a general multi-
parameter exponential family setting, based on generalized likelihood ratio statistics and optimal
sequential tes...
Efficient adaptive designs with mid-course sample size adjustment in clinical trials
adaptive design conditional power futility Kullback-Leibler information sample size re-estimation
2011/6/17
Adaptive designs have been proposed for clinical trials in which the nuisance parameters
or alternative of interest are unknown or likely to be misspecified before the trial. Whereas most
previous w...
Handling Covariates in the Design of Clinical Trials
Balance covariate-adaptive randomization covariate-adjusted response-adaptive randomization effi ciency ethics
2011/3/23
There has been a split in the statistics community about the need for taking covariates into account in the design phase of a clinical trial. There are many advocates of using stratification and covar...
Handling Covariates in the Design of Clinical Trials
Balance covariate-adaptive randomization covariate-adjusted response-adaptive randomization effi ciency ethics
2011/3/22
There has been a split in the statistics community about the need for taking covariates into account in the design phase of a clinical trial. There are many advocates of using stratification and covar...
Impact of Socioeconomic Disparities and Education on Trauma –Induced Clinical Complications
Socioeconomic Disparities Education Trauma Clinical Complications
2009/10/26
Objective: This study is conducted to investigate the impact of social status including unemployment and education on the outcomes of clinical complications after traumatic injury. Study design and me...
Postoperative outcome of caesarean sections and other major emergency obstetric surgery by clinical officers and medical officers in Malawi
postoperative outcome caesarean sections clinical officers medical officers Malawi
2009/9/27
Clinical officers perform the bulk of emergency obstetric operations at district hospitals in Malawi. The postoperative outcomes of their procedures are comparable to those of medical officers. Clinic...
A cost-effectiveness study of caesarean-section deliveries by clinical officers, general practitioners and obstetricians in Burkina Faso
cost-effectiveness study caesarean-section deliveries clinical officers general practitioners obstetricians Burkina Faso
2009/9/27
Training substitutes is a viable option to increase access to life-saving operations in district hospitals. The high newborn case fatality rate among clinical officers could be addressed by a refreshe...
A LIKELIHOOD APROACH TO DIAGNOSTIC TESTS IN CLINICAL MEDICINE
credibility diagnosability likelihood plausibility sensitivity signicance specicity
2009/2/26
This paper presents a pure likelihood approach to statistical inference and its rela-
tion to diagnostic tests in clinical medicine. The standard antagonistic frequentist
approaches of Fisher and Ne...
Incorporating patients’ characteristics in cost-effectiveness studies with clinical trial data：a flexible Bayesian approach
Bayesian analysis cost-effectiveness Markov Chain Monte Carlo （MCMC） skewed cost distributions
2009/2/23
Most published research on the comparison between medical treatment options merely compares the
results (effectiveness and cost) obtained for each treatment group. The present work proposes the incor...
Modeling long-term longitudinal HIV dynamics with application to an AIDS clinical study
AIDS antiretroviral drug therapy Bayesian nonlinear mixedeffectsmodels time-varying drug efficacy long-term HIV dynamics longitudinal data
2010/3/17
A virologic marker, the number of HIV RNA copies or viral load,
is currently used to evaluate antiretroviral (ARV) therapies in AIDS
clinical trials. This marker can be used to assess the ARV potenc...