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Colocalization of the Ganglioside GM1 and Cholesterol Detected by Secondary Ion Mass Spectrometry
Cholesterol G(M1) Ganglioside Lipid Bilayers Spectrometry, Mass, Secondary Ion Molecular Conformation Biological Transport Microtechnology Nanotechnology Models, Molecular
2016/5/25
The characterization of the lateral organization of components in biological membranes and the evolution of this arrangement in response to external triggers remain a major challenge. The concept of l...
Supported Membrane Composition Analysis by Secondary Ion Mass Spectrometry with High Lateral Resolution
cryosolvents sugar glass glycerol water trytophan indole IR flourescence phosphorescence
2016/5/24
The lateral organization of lipid components within membranes is usually investigated with fluorescence microscopy, which, though highly sensitive, introduces bulky fluorophores that might alter the b...
Chemical cross-linking/mass spectrometry targeting acidic residues in proteins and protein complexes.
Chemical cross-linking/mass spectrometry targeting acidic residues proteins protein complexes.
2015/12/11
The study of proteins and protein complexes using chemical cross-linking followed by the MS identification of the cross-linked peptides has found increasingly widespread use in recent years. Thus far,...
Structural Analysis of Proteins by Covalent Labeling and Mass Spectrometric Detection
mass spectrometry protein 3D structure
2014/11/20
Covalent labeling and mass spectrometry are seeing increased use together as a way to obtain insight into the 3-dimensional structure of proteins and protein complexes. Several amino acid specific (e....
Enhanced Detection Strategies Accomplished Through Metal Binding and Miniature Mass Spectrometry
Metal binding Miniaturization Multiplexed MS/MS
2014/11/20
A multiplexed method for performing MS/MS on multiple ions simultaneously in a miniature rectilinear ion trap (RIT) mass spectrometer has been developed. This method uses an ion encoding procedure tha...
Development of Mass Spectrometry-Based Methods for Quantitation and Characterization of Protein Drugs: Transferrin as a Model Drug Delivery Vehicle
Mass Spectrometry O18 labeling Protein quantitation Transferrin
2014/11/20
In the last two decades, protein drugs have enjoyed a rapid growth and achieved a tremendous success in treating human diseases. However, the presence of physiological barriers greatly impedes the eff...
Application of Laser Ablation-Inductively Coupled Plasma-Mass Spectrometry to studies of chemical diffusion, sorption, and transport in natural rock
imbibition diffusion sorption transport rock
2017/4/11
We applied laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS) techniques to make spatial
measurements of chemical tracer concentrations in three natural rock types (tuff, sandsto...
Liquid chromatography/mass spectrometry analysis of perfluoroalkyl carboxylic acids and perfluorooctanesulfonate in bivalve shells: Extraction method optimization
Perfluorinated carboxylic acids Perfluorooctanesulfonate Shell Soft tissue Acid digestion Solid phase extraction
2013/12/12
Different extraction methods, including extraction by organic solvents with and without acetic acid digestion,and mixed inorganic acid digestion coupled with solid phase extraction (SPE), were develop...
Synthesis, spectroscopic characterization, mass spectrometry, and crystal structure of N-{[(4-bromophenyl)amino]carbonothioyl}benzamide
Thiourea derivative X-ray structure determination mass fragmentation
2010/12/3
N-{[(4-bromophenyl)amino]carbonothioyl}benzamide was synthesized and characterized by IR, 1H- and 13C-NMR, mass spectrometry, and elemental analysis. The crystal structure was determined from single c...
Synthesis, Spectroscopic Characterization, Mass Spectrometry and Crystal Structure of N-{[(4-bromophenyl) amino]carbonothioyl}benzamide
Thiourea derivative X-ray structure determination mass fragmentation
2010/10/19
N-{[(4-bromophenyl)amino]carbonothioyl}benzamide was synthesized and characterized by IR, 1 H- and 13C-NMR, mass spectrometry, and elemental analysis. The crystal structure was determined from single ...
Do we always need Mass Spectrometry?
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2010/12/21
The detector, as well as being an essential supporting device for the gas chromatography (GC) has also played a critical role in the development of the technique as a whole. The mass spectrometer (MS)...
Illuminated darkness: Molecular signatures of Congo River dissolved organic matter and its photochemical alteration as revealed by ultrahigh precision mass spectrometry
Illuminated darkness Molecular signatures of Congo River organic matter its photochemical alteration ultrahigh precision mass spectrometry
2014/4/17
Congo River water was filtered and then irradiated for 57 d in a solar simulator, resulting in extensive photodegradation of dissolved organic matter (DOM). Whole-water (i.e., unfractionated) DOM was ...
Trace Analysis of Polycyclic Aromatic Hydrocarbons Using Gas Chromatography–Mass Spectrometry Based on Nanosecond Multiphoton Ionization
Trace Analysis Polycyclic Aromatic Hydrocarbons Gas Chromatography–Mass Spectrometry Based Nanosecond Multiphoton Ionization
2010/9/15
Gas chromatography/resonance-enhanced multiphoton ionization/time-of-flight mass spectrometry (GC/REMPI-TOFMS) using an ultraviolet nanosecond laser was employed in the trace analysis of polycyclic ar...
Traceable Amino Acid Analyses of Proteins and Peptides by Isotope-Dilution Mass Spectrometry Using Precolumn Derivatization Reagent
Traceable Amino Acid Analyses Proteins and Peptides Isotope-Dilution Mass Spectrometry
2010/9/17
We have developed an accurate and traceable quantitation method of proteins and peptides by isotope-dilution mass spectrometry with the precolumn derivatization for hydrolyzed amino acid. This method ...
Visualization of Spatial Distribution of γ-Aminobutyric Acid in Eggplant (Solanum melongena) by Matrix-assisted Laser Desorption/Ionization Imaging Mass Spectrometry
Visualization Spatial Distribution γ-Aminobutyric Acid
2010/9/14
We applied imaging mass spectrometry (IMS) to determine the spatial distribution of γ-aminobutyric acid (GABA). We found that GABA had a specific localization in seeds. We also visualized various biom...